Assay Detail
Binding
CHEMBL2189046
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Inhibition of equine BuChE after 120 mins by Ellman's method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.68 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177713 | — | — | 1 | 8.10 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 6.80 |
| CHEMBL3217012 | — | — | 1 | 6.70 |
| CHEMBL2181475 | — | — | 1 | 6.52 |
| CHEMBL2177700 | — | — | 1 | 6.52 |
| CHEMBL255231 | LADOSTIGIL | 2.0 | 1 | 6.32 |
| CHEMBL2177699 | — | — | 1 | 6.25 |
| CHEMBL2177716 | — | — | 1 | 6.16 |
| CHEMBL2177715 | — | — | 1 | 6.16 |
| CHEMBL2177714 | — | — | 1 | 5.89 |
| CHEMBL2177708 | — | — | 1 | 5.41 |
| CHEMBL2177704 | — | — | 1 | 5.34 |
| CHEMBL2177718 | — | — | 1 | 5.17 |
| CHEMBL2177698 | — | — | 1 | 5.17 |
| CHEMBL2177702 | — | — | 1 | 5.07 |
| CHEMBL2177720 | — | — | 1 | 5.02 |
| CHEMBL2177701 | — | — | 1 | 5.01 |
| CHEMBL2177709 | — | — | 1 | 5.00 |
| CHEMBL2177712 | — | — | 1 | 4.27 |
| CHEMBL2177717 | — | — | 1 | 4.23 |
| CHEMBL2177711 | — | — | 1 | 4.17 |
| CHEMBL2177706 | — | — | 1 | - |
| CHEMBL2177705 | — | — | 1 | - |
| CHEMBL2177707 | — | — | 1 | - |
| CHEMBL2177703 | — | — | 1 | - |
| CHEMBL2177111 | — | — | 1 | - |
| CHEMBL2177710 | — | — | 1 | - |
| CHEMBL2177723 | — | — | 1 | - |
| CHEMBL2177721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177713 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3217012 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2181475 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2177700 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL255231 | LADOSTIGIL | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2177699 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2177716 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2177715 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2177714 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2177708 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2177704 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2177718 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2177698 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2177702 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2177720 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2177701 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL2177709 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2177712 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2177717 | — | IC50 | = | 58700.0 | nM | 4.23 |
| CHEMBL2177711 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL2177706 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL2177705 | — | IC50 | = | 417000.0 | nM | - |
| CHEMBL2177707 | — | IC50 | > | 600000.0 | nM | - |
| CHEMBL2177703 | — | IC50 | = | 197000.0 | nM | - |
| CHEMBL2177111 | — | IC50 | = | 372000.0 | nM | - |
| CHEMBL2177710 | — | IC50 | = | 404000.0 | nM | - |
| CHEMBL2177723 | — | IC50 | - | — | - | |
| CHEMBL2177721 | — | IC50 | - | — | - |