Assay Detail

CHEMBL2208595

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of HCV 3a NS3 protease

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Hepatitis C virus subtype 3a
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

Marsault E, Peterson ML.
J Med Chem (2011) 54 : 1961 -2004
PubMed 21381769 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.92	8.92
IC50	1	9.70	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL258734	DANOPREVIR	3.0	1	9.70
CHEMBL2204317	—	—	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL258734	DANOPREVIR	IC50	=	0.2	nM	9.70
CHEMBL2204317	—	Ki	=	1.2	nM	8.92