Assay Detail
Functional
CHEMBL2208596
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Antiviral activity against HCV by cell based replicon assay
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.44 | 8.74 |
| IC50 | 2 | 7.26 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.74 |
| CHEMBL2204317 | — | — | 1 | 8.70 |
| CHEMBL2204318 | — | — | 1 | 8.17 |
| CHEMBL295844 | — | — | 1 | 8.15 |
| CHEMBL2204319 | — | — | 1 | 8.06 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2204317 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2204318 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL295844 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2204319 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL231813 | TELAPREVIR | IC50 | = | 354.0 | nM | 6.45 |