Assay Detail
Binding
CHEMBL2208599
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Inhibition of HCV NS3 protease
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 9.00 |
| Ki | 2 | 9.74 | 9.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204319 | — | — | 1 | 9.74 |
| CHEMBL266889 | — | — | 1 | 9.00 |
| CHEMBL265531 | — | — | 1 | 5.16 |
| CHEMBL2204318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204319 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL266889 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL265531 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2204318 | — | Ki | < | 0.016 | nM | - |