Assay Detail
Binding
CHEMBL2208607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV protease
12
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 9.26 | 10.92 |
| IC50 | 3 | 7.67 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571882 | — | — | 2 | 10.92 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 10.82 |
| CHEMBL578406 | — | — | 2 | 10.22 |
| CHEMBL1233239 | — | — | 1 | 9.22 |
| CHEMBL2204321 | — | — | 2 | 9.15 |
| CHEMBL2204323 | — | — | 1 | 8.74 |
| CHEMBL2204322 | — | — | 1 | 8.52 |
| CHEMBL1235296 | — | — | 1 | 7.92 |
| CHEMBL2204333 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571882 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL1323 | DARUNAVIR | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL578406 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL1233239 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2204321 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL2204323 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2204322 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL571882 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL578406 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1235296 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2204333 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2204321 | — | IC50 | = | 300.0 | nM | 6.52 |