Assay Detail

CHEMBL2208699

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antagonist activity at angiotensin 1 receptor

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Type-1 angiotensin II receptor (CHEMBL227) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Type-1 angiotensin II receptor (CHEMBL227) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Type-1 angiotensin II receptor

CHEMBL227

Anchored from Assay target.

Protein identity Type-1 angiotensin II receptor

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Type-1 angiotensin II receptor (CHEMBL227) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synopsis of some recent tactical application of bioisosteres in drug design.

Meanwell NA.
J Med Chem (2011) 54 : 2529 -2591
PubMed 21413808 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	9.61	9.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL293511	—	—	1	9.70
CHEMBL7550	L-158809	—	1	9.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL293511	—	IC50	=	0.2	nM	9.70
CHEMBL7550	L-158809	IC50	=	0.3	nM	9.52