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Assay Detail

CHEMBL2208797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of nAChR-mediated twitch response in mouse hemidiaphragm
30
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

16-morpholino quaternary ammonium steroidal derivatives as neuromuscular blocking agents: synthesis, biological evaluation and in silico probe of ligand-receptor interaction.
Hu H, Rao Z, Xu J, Zhu Q, Altenbach HJ, Chen H, Zhou D, Xiao Y, Ke X, Guo H, Wu Z, Liu P, Hu X.
Eur J Med Chem (2012) 56 : 332 -347
PubMed 22910136 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.91 6.51
IC90 10 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1200629 VECURONIUM BROMIDE 4.0 2 6.51
CHEMBL1200648 ROCURONIUM BROMIDE 4.0 2 5.60
CHEMBL2203367 2 5.46
CHEMBL2203370 2 5.34
CHEMBL2203365 2 4.97
CHEMBL2203369 2 4.90
CHEMBL2203366 2 4.88
CHEMBL2203360 1 4.87
CHEMBL2203362 1 4.79
CHEMBL2203364 2 4.78
CHEMBL2203341 1 4.76
CHEMBL2203342 1 4.73
CHEMBL2203363 1 4.73
CHEMBL2203340 2 4.70
CHEMBL2203357 1 4.67
CHEMBL2203359 1 4.61
CHEMBL2203358 1 4.56
CHEMBL2203368 2 4.47
CHEMBL2203343 1 4.41
CHEMBL2203361 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1200629 VECURONIUM BROMIDE IC50 = 310.0 nM 6.51
CHEMBL1200648 ROCURONIUM BROMIDE IC50 = 2500.0 nM 5.60
CHEMBL2203367 IC50 = 3490.0 nM 5.46
CHEMBL2203370 IC50 = 4540.0 nM 5.34
CHEMBL2203365 IC50 = 10700.0 nM 4.97
CHEMBL2203369 IC50 = 12680.0 nM 4.90
CHEMBL2203366 IC50 = 13130.0 nM 4.88
CHEMBL2203360 IC50 = 13600.0 nM 4.87
CHEMBL2203362 IC50 = 16160.0 nM 4.79
CHEMBL2203364 IC50 = 16650.0 nM 4.78
CHEMBL2203341 IC50 = 17410.0 nM 4.76
CHEMBL2203363 IC50 = 18490.0 nM 4.73
CHEMBL2203342 IC50 = 18550.0 nM 4.73
CHEMBL2203340 IC50 = 19810.0 nM 4.70
CHEMBL2203357 IC50 = 21430.0 nM 4.67
CHEMBL2203359 IC50 = 24470.0 nM 4.61
CHEMBL2203358 IC50 = 27640.0 nM 4.56
CHEMBL2203368 IC50 = 33910.0 nM 4.47
CHEMBL2203361 IC50 = 38930.0 nM 4.41
CHEMBL2203343 IC50 = 39070.0 nM 4.41
CHEMBL2203364 IC90 = 24960.0 nM -
CHEMBL2203365 IC90 = 15700.0 nM -
CHEMBL2203366 IC90 = 18580.0 nM -
CHEMBL2203367 IC90 = 5460.0 nM -
CHEMBL2203368 IC90 = 50720.0 nM -
CHEMBL2203369 IC90 = 18160.0 nM -
CHEMBL2203370 IC90 = 6380.0 nM -
CHEMBL2203340 IC90 = 29370.0 nM -
CHEMBL1200629 VECURONIUM BROMIDE IC90 = 440.0 nM -
CHEMBL1200648 ROCURONIUM BROMIDE IC90 = 3530.0 nM -