Assay Detail
Binding
CHEMBL2209109
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT3 using histone H3 as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.20 | 4.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204997 | — | — | 1 | 4.27 |
| CHEMBL2204995 | — | — | 1 | 4.13 |
| CHEMBL2204998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204997 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL2204995 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL2204998 | — | IC50 | > | 100000.0 | nM | - |