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Assay Detail

CHEMBL2209156

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Functional
Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHOp
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.
Chen J, Collins GT, Levant B, Woods J, Deschamps JR, Wang S.
ACS Med Chem Lett (2011) 2 : 620 -625
PubMed 22125662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.77 8.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2203406 1 8.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2203406 EC50 = 1.7 nM 8.77