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Assay Detail

CHEMBL2209273

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against african green monkey Vero cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

Recent advances in antitubercular natural products.
García A, Bocanegra-García V, Palma-Nicolás JP, Rivera G.
Eur J Med Chem (2012) 49 : 1 -23
PubMed 22280816 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.93 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL340160 ASCIDIDEMIN 1 6.85
CHEMBL2205109 RAMIFERIN 1 5.01
CHEMBL2204405 1 -
CHEMBL2205089 FISCHAMBIGUINE B 1 -
CHEMBL2205088 PARGUESTEROL B 1 -
CHEMBL521161 PARGUESTEROL A 1 -
CHEMBL2204430 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL340160 ASCIDIDEMIN IC50 = 140.0 nM 6.85
CHEMBL2205109 RAMIFERIN IC50 = 9700.0 nM 5.01
CHEMBL2204405 IC50 = 0.33 ug.mL-1 -
CHEMBL2205089 FISCHAMBIGUINE B IC50 = 128000.0 nM -
CHEMBL2205088 PARGUESTEROL B IC50 = 52.0 ug.mL-1 -
CHEMBL521161 PARGUESTEROL A IC50 = 52.0 ug.mL-1 -
CHEMBL2204430 IC50 = 2.58 ug.mL-1 -