Assay Detail
Functional
CHEMBL2209399
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Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.05 | 4.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276618 | 4-METHYLDAPHNETIN | — | 1 | 4.08 |
| CHEMBL313244 | 4-METHYLESCULETIN | — | 1 | 4.01 |
| CHEMBL2205242 | — | — | 1 | - |
| CHEMBL458049 | — | — | 1 | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | — | 1 | - |
| CHEMBL136927 | DIHYDROCAFFEIC ACID | — | 1 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
| CHEMBL2205241 | — | — | 1 | - |
| CHEMBL54907 | 4-HYDROXY-6-METHYLPYRAN-2-ONE | — | 1 | - |
| CHEMBL372284 | — | — | 1 | - |
| CHEMBL1934663 | — | — | 1 | - |
| CHEMBL12626 | — | — | 1 | - |
| CHEMBL6703 | — | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
| CHEMBL1784035 | — | — | 1 | - |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | - |
| CHEMBL2205240 | — | — | 1 | - |
| CHEMBL71851 | SCOPOLETIN | — | 1 | - |
| CHEMBL325864 | SCOPARONE | — | 1 | - |
| CHEMBL1980149 | — | — | 1 | - |
| CHEMBL12252 | 5,7-DIHYDROXY-4-METHYLCOUMARIN | — | 1 | - |
| CHEMBL244743 | ESCULETIN | — | 1 | - |
| CHEMBL54909 | FRAXETIN | — | 1 | - |
| CHEMBL270672 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276618 | 4-METHYLDAPHNETIN | IC50 | = | 83200.0 | nM | 4.08 |
| CHEMBL313244 | 4-METHYLESCULETIN | IC50 | = | 97400.0 | nM | 4.01 |
| CHEMBL2205242 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL458049 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | IC50 | > | 2000000.0 | nM | - |
| CHEMBL136927 | DIHYDROCAFFEIC ACID | IC50 | = | 212700.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 316500.0 | nM | - |
| CHEMBL2205241 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL54907 | 4-HYDROXY-6-METHYLPYRAN-2-ONE | IC50 | > | 2000000.0 | nM | - |
| CHEMBL372284 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1934663 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL12626 | — | IC50 | = | 627700.0 | nM | - |
| CHEMBL6703 | — | IC50 | = | 258700.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | IC50 | > | 2000000.0 | nM | - |
| CHEMBL1784035 | — | IC50 | = | 453700.0 | nM | - |
| CHEMBL12208 | HYMECROMONE | IC50 | = | 710900.0 | nM | - |
| CHEMBL2205240 | — | IC50 | = | 771300.0 | nM | - |
| CHEMBL71851 | SCOPOLETIN | IC50 | = | 975900.0 | nM | - |
| CHEMBL325864 | SCOPARONE | IC50 | = | 589900.0 | nM | - |
| CHEMBL1980149 | — | IC50 | = | 736100.0 | nM | - |
| CHEMBL12252 | 5,7-DIHYDROXY-4-METHYLCOUMARIN | IC50 | > | 2000000.0 | nM | - |
| CHEMBL244743 | ESCULETIN | IC50 | = | 143100.0 | nM | - |
| CHEMBL54909 | FRAXETIN | IC50 | = | 142900.0 | nM | - |
| CHEMBL270672 | — | IC50 | > | 2000000.0 | nM | - |