Assay Detail
Binding
CHEMBL2209784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus A/Udorn/1972(H3N2) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/udorn/1972(H3N2)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL2046263) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Udorn/307/1972 H3N2) |
Publication
Development of oseltamivir phosphonate congeners as anti-influenza agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.30 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206459 | — | — | 1 | 9.46 |
| CHEMBL2206456 | TAMIPHOSPHOR | — | 1 | 8.80 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.54 |
| CHEMBL2206458 | TAMIPHOSPHOR MONOETHYL ESTER | — | 1 | 8.42 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.64 |
| CHEMBL2206932 | TAMIPHOSPHOR MONOETHYL ESTER | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206459 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL2206456 | TAMIPHOSPHOR | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2206458 | TAMIPHOSPHOR MONOETHYL ESTER | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL2206932 | TAMIPHOSPHOR MONOETHYL ESTER | IC50 | = | 114.0 | nM | 6.94 |