Assay Detail
Binding
CHEMBL2209790
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Inhibition of Influenza A virus A/Taiwan/3446/2002(H3N2) neuraminidase in virus-infected allantoic fluid using 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid as substrate incubated for 10 mins prior to substrate addition by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of oseltamivir phosphonate congeners as anti-influenza agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.29 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206459 | — | — | 1 | 9.52 |
| CHEMBL2206456 | TAMIPHOSPHOR | — | 1 | 8.74 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 8.51 |
| CHEMBL2206458 | TAMIPHOSPHOR MONOETHYL ESTER | — | 1 | 8.23 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 7.86 |
| CHEMBL2206932 | TAMIPHOSPHOR MONOETHYL ESTER | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206459 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2206456 | TAMIPHOSPHOR | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2206458 | TAMIPHOSPHOR MONOETHYL ESTER | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL2206932 | TAMIPHOSPHOR MONOETHYL ESTER | IC50 | = | 131.7 | nM | 6.88 |