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Assay Detail

CHEMBL2209965

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Binding
Inhibition of soybean 15-LOX assessed as peroxide level by DMAB-MBTH method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as potent 15-lipoxygenase inhibitors.
Assadieskandar A, Amini M, Salehi M, Sadeghian H, Alimardani M, Sakhteman A, Nadri H, Shafiee A.
Bioorg Med Chem (2012) 20 : 7160 -7166
PubMed 23117172 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.80 5.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2207969 1 5.33
CHEMBL2207965 1 5.24
CHEMBL2207967 1 5.03
CHEMBL2207968 1 4.96
CHEMBL2207963 1 4.86
CHEMBL342031 1 4.83
CHEMBL2207973 1 4.82
CHEMBL2207971 1 4.71
CHEMBL2207966 1 4.65
CHEMBL2207974 1 4.63
CHEMBL2207964 1 4.60
CHEMBL437540 1 4.47
CHEMBL2207975 1 4.21
CHEMBL2207972 1 -
CHEMBL2207970 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2207969 IC50 = 4700.0 nM 5.33
CHEMBL2207965 IC50 = 5700.0 nM 5.24
CHEMBL2207967 IC50 = 9400.0 nM 5.03
CHEMBL2207968 IC50 = 11000.0 nM 4.96
CHEMBL2207963 IC50 = 13700.0 nM 4.86
CHEMBL342031 IC50 = 14700.0 nM 4.83
CHEMBL2207973 IC50 = 15200.0 nM 4.82
CHEMBL2207971 IC50 = 19700.0 nM 4.71
CHEMBL2207966 IC50 = 22300.0 nM 4.65
CHEMBL2207974 IC50 = 23400.0 nM 4.63
CHEMBL2207964 IC50 = 24900.0 nM 4.60
CHEMBL437540 IC50 = 34200.0 nM 4.47
CHEMBL2207975 IC50 = 62000.0 nM 4.21
CHEMBL2207972 IC50 > 250000.0 nM -
CHEMBL2207970 IC50 = 136000.0 nM -