Assay Detail
Binding
CHEMBL2210075
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Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.32 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206129 | — | — | 1 | 9.96 |
| CHEMBL2206123 | — | — | 1 | 9.80 |
| CHEMBL2206130 | — | — | 1 | 9.34 |
| CHEMBL2206119 | — | — | 1 | 9.34 |
| CHEMBL2205576 | — | — | 1 | 9.33 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.85 |
| CHEMBL2205575 | — | — | 1 | 7.58 |
| CHEMBL2206126 | — | — | 1 | 7.12 |
| CHEMBL2206120 | — | — | 1 | 7.07 |
| CHEMBL2206121 | — | — | 1 | 6.92 |
| CHEMBL2206118 | — | — | 1 | 6.48 |
| CHEMBL2206122 | — | — | 1 | 6.36 |
| CHEMBL2205577 | — | — | 1 | 6.33 |
| CHEMBL2205573 | — | — | 1 | 6.27 |
| CHEMBL2205574 | — | — | 1 | 6.12 |
| CHEMBL2206124 | — | — | 1 | 6.10 |
| CHEMBL2206128 | — | — | 1 | 5.83 |
| CHEMBL2206127 | — | — | 1 | 5.80 |
| CHEMBL2206125 | — | — | 1 | 5.44 |
| CHEMBL2203310 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206129 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL2206123 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2206130 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL2206119 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL2205576 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2205575 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2206126 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL2206120 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2206121 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2206118 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2206122 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2205577 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL2205573 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2205574 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2206124 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2206128 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL2206127 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2206125 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL2203310 | — | IC50 | - | — | - |