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Assay Detail

CHEMBL2210436

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to uPAR
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Urokinase plasminogen activator surface receptor (CHEMBL4883)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and docking studies of novel antitumor benzimidazoles.
Omar MA, Shaker YM, Galal SA, Ali MM, Kerwin SM, Li J, Tokuda H, Ramadan RA, El Diwani HI.
Bioorg Med Chem (2012) 20 : 6989 -7001
PubMed 23123017 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 9.74 10.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2206698 1 10.96
CHEMBL2206697 1 10.92
CHEMBL2206687 1 10.48
CHEMBL2206686 1 9.53
CHEMBL2206682 1 8.88
CHEMBL1652555 1 7.68
CHEMBL2206680 1 -
CHEMBL2206700 1 -
CHEMBL2206699 1 -
CHEMBL2206696 1 -
CHEMBL2206695 1 -
CHEMBL2206694 1 -
CHEMBL2206693 1 -
CHEMBL2206692 1 -
CHEMBL2206681 1 -
CHEMBL2206690 1 -
CHEMBL2206689 1 -
CHEMBL2206688 1 -
CHEMBL2206685 1 -
CHEMBL2206684 1 -
CHEMBL2206683 1 -
CHEMBL2206691 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2206698 Ki = 0.011 nM 10.96
CHEMBL2206697 Ki = 0.012 nM 10.92
CHEMBL2206687 Ki = 0.0333 nM 10.48
CHEMBL2206686 Ki = 0.296 nM 9.53
CHEMBL2206682 Ki = 1.33 nM 8.88
CHEMBL1652555 Ki = 20.8 nM 7.68
CHEMBL2206680 Ki = 0.00153 nM -
CHEMBL2206700 Ki = 0.00445 nM -
CHEMBL2206699 Ki = 0.0044 nM -
CHEMBL2206696 Ki = 0.001 nM -
CHEMBL2206695 Ki = 0.00653 nM -
CHEMBL2206694 Ki = 0.000589 nM -
CHEMBL2206693 Ki = 0.00302 nM -
CHEMBL2206692 Ki = 0.00329 nM -
CHEMBL2206681 Ki = 0.00217 nM -
CHEMBL2206690 Ki = 0.00327 nM -
CHEMBL2206689 Ki = 0.00411 nM -
CHEMBL2206688 Ki = 0.00759 nM -
CHEMBL2206685 Ki = 0.0017 nM -
CHEMBL2206684 Ki = 0.000288 nM -
CHEMBL2206683 Ki = 0.00636 nM -
CHEMBL2206691 Ki = 0.00227 nM -