Assay Detail
Binding
CHEMBL2211170
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Modulation of gamma-secretase assessed as reduction in amyloid beta 42 level by cell based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a natural product-based class of γ-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.06 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207469 | — | — | 1 | 7.33 |
| CHEMBL2152863 | — | — | 1 | 7.22 |
| CHEMBL1224151 | — | — | 1 | 7.21 |
| CHEMBL2152860 | — | — | 1 | 7.00 |
| CHEMBL2169963 | — | — | 1 | 7.00 |
| CHEMBL2151284 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207469 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL2152863 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1224151 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2152860 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2169963 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2151284 | — | IC50 | = | 260.0 | nM | 6.58 |