Assay Detail
Binding
CHEMBL2211272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DAT
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.97 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206529 | — | — | 1 | 7.97 |
| CHEMBL2206533 | — | — | 1 | 7.67 |
| CHEMBL2206532 | — | — | 1 | 7.60 |
| CHEMBL2206535 | — | — | 1 | 7.57 |
| CHEMBL2206526 | — | — | 1 | 7.52 |
| CHEMBL2206509 | — | — | 1 | 7.44 |
| CHEMBL2206507 | — | — | 1 | 7.44 |
| CHEMBL2206523 | — | — | 2 | 7.42 |
| CHEMBL2206510 | — | — | 1 | 7.39 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 2 | 7.37 |
| CHEMBL2206525 | — | — | 1 | 7.35 |
| CHEMBL2206528 | — | — | 1 | 7.24 |
| CHEMBL2206527 | — | — | 1 | 7.21 |
| CHEMBL2206534 | — | — | 1 | 7.19 |
| CHEMBL2206508 | — | — | 1 | 7.11 |
| CHEMBL2206531 | — | — | 1 | 7.11 |
| CHEMBL2206518 | — | — | 1 | 7.09 |
| CHEMBL2206524 | — | — | 1 | 7.00 |
| CHEMBL2206536 | — | — | 1 | 6.97 |
| CHEMBL2206520 | — | — | 1 | 6.97 |
| CHEMBL2206516 | — | — | 1 | 6.95 |
| CHEMBL2206514 | — | — | 1 | 6.89 |
| CHEMBL2206513 | — | — | 1 | 6.80 |
| CHEMBL2206521 | — | — | 1 | 6.76 |
| CHEMBL2206519 | — | — | 1 | 6.68 |
| CHEMBL207867 | — | — | 1 | 6.64 |
| CHEMBL2206517 | — | — | 1 | 6.63 |
| CHEMBL2206512 | — | — | 1 | 6.56 |
| CHEMBL2206511 | — | — | 1 | 6.54 |
| CHEMBL2206515 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206529 | — | Ki | = | 10.6 | nM | 7.97 |
| CHEMBL2206533 | — | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL2206532 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2206535 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2206526 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL2206509 | — | Ki | = | 36.2 | nM | 7.44 |
| CHEMBL2206507 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2206523 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL2206510 | — | Ki | = | 40.5 | nM | 7.39 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL2206525 | — | Ki | = | 44.7 | nM | 7.35 |
| CHEMBL2206528 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL2206527 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2206534 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL2206531 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2206508 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL2206518 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL2206524 | — | Ki | = | 98.8 | nM | 7.00 |
| CHEMBL2206520 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL2206536 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL2206516 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL2206514 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL2206513 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL2206521 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL2206519 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL207867 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL2206517 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL2206512 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL2206511 | — | Ki | = | 291.0 | nM | 6.54 |
| CHEMBL2206523 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL2206515 | — | Ki | = | 371.0 | nM | 6.43 |
| CHEMBL2206530 | — | Ki | = | 687.0 | nM | 6.16 |
| CHEMBL2206522 | — | Ki | = | 1840.0 | nM | 5.74 |
| CHEMBL400964 | — | Ki | = | 13400.0 | nM | 4.87 |