Assay Detail
Binding
CHEMBL2211273
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Inhibition of human NET
36
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.41 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206526 | — | — | 1 | 8.36 |
| CHEMBL2206507 | — | — | 1 | 8.30 |
| CHEMBL2206508 | — | — | 1 | 8.24 |
| CHEMBL1175 | DULOXETINE | 4.0 | 1 | 8.22 |
| CHEMBL2206509 | — | — | 1 | 8.15 |
| CHEMBL2206532 | — | — | 1 | 8.14 |
| CHEMBL2206525 | — | — | 1 | 8.14 |
| CHEMBL2206531 | — | — | 1 | 8.05 |
| CHEMBL2206524 | — | — | 1 | 7.91 |
| CHEMBL2206534 | — | — | 1 | 7.89 |
| CHEMBL2206527 | — | — | 1 | 7.87 |
| CHEMBL2206536 | — | — | 1 | 7.85 |
| CHEMBL2206535 | — | — | 1 | 7.82 |
| CHEMBL2206533 | — | — | 1 | 7.78 |
| CHEMBL2206529 | — | — | 1 | 7.72 |
| CHEMBL273575 | NOMIFENSINE | 4.0 | 2 | 7.67 |
| CHEMBL2206523 | — | — | 2 | 7.55 |
| CHEMBL2206530 | — | — | 1 | 7.54 |
| CHEMBL2206518 | — | — | 1 | 7.50 |
| CHEMBL2206511 | — | — | 1 | 7.46 |
| CHEMBL2206516 | — | — | 1 | 7.46 |
| CHEMBL2206528 | — | — | 1 | 7.43 |
| CHEMBL2206510 | — | — | 1 | 7.33 |
| CHEMBL2206517 | — | — | 1 | 7.27 |
| CHEMBL2206512 | — | — | 1 | 7.00 |
| CHEMBL2206520 | — | — | 1 | 6.94 |
| CHEMBL2206519 | — | — | 1 | 6.94 |
| CHEMBL207867 | — | — | 1 | 6.87 |
| CHEMBL2206513 | — | — | 1 | 6.87 |
| CHEMBL2206514 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206526 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL2206507 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2206508 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL1175 | DULOXETINE | Ki | = | 5.97 | nM | 8.22 |
| CHEMBL2206509 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL2206532 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL2206525 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL2206531 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL2206524 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL2206534 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL2206527 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL2206536 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL2206535 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2206533 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL2206529 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 21.5 | nM | 7.67 |
| CHEMBL273575 | NOMIFENSINE | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2206523 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL2206530 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2206518 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL2206511 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2206516 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL2206528 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL2206510 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2206517 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL2206512 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2206519 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL2206520 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL207867 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL2206513 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL2206514 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL2206515 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL2206523 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL2206522 | — | Ki | = | 806.0 | nM | 6.09 |
| CHEMBL2206521 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL400964 | — | Ki | = | 6450.0 | nM | 5.19 |