Assay Detail
Binding
CHEMBL2212125
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Binding affinity to TRbeta1
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.62 | 10.22 |
| EC50 | 2 | 8.94 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203777 | — | — | 1 | 10.22 |
| CHEMBL41036 | — | — | 1 | 9.43 |
| CHEMBL2203702 | — | — | 1 | 9.33 |
| CHEMBL235788 | — | — | 1 | 8.54 |
| CHEMBL471897 | MB07811 | 2.0 | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203777 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL41036 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL2203702 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL235788 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL471897 | MB07811 | Ki | = | 600.0 | nM | 6.22 |