Assay Detail
Binding
CHEMBL2212191
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Inhibition of Hsp90alpha
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
EC144 is a potent inhibitor of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.66 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2205798 | — | — | 1 | 9.15 |
| CHEMBL2205245 | — | — | 1 | 9.00 |
| CHEMBL1230584 | — | — | 1 | 8.96 |
| CHEMBL2205799 | — | — | 1 | 8.70 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 8.52 |
| CHEMBL2205800 | — | — | 1 | 8.41 |
| CHEMBL467399 | BIIB021 | 2.0 | 1 | 8.29 |
| CHEMBL2205244 | — | — | 1 | 8.22 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2205798 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2205245 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1230584 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2205799 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL560895 | SNX-2112 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2205800 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL467399 | BIIB021 | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2205244 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL252164 | LUMINESPIB | IC50 | < | 0.4 | nM | - |