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Assay Detail

CHEMBL2212643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at Grp94 incubated for 16 hrs by fluorescence polarization competition assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Endoplasmin (CHEMBL1075323)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

EC144 is a potent inhibitor of the heat shock protein 90.
Shi J, Van de Water R, Hong K, Lamer RB, Weichert KW, Sandoval CM, Kasibhatla SR, Boehm MF, Chao J, Lundgren K, Timple N, Lough R, Ibanez G, Boykin C, Burrows FJ, Kehry MR, Yun TJ, Harning EK, Ambrose C, Thompson J, Bixler SA, Dunah A, Snodgrass-Belt P, Arndt J, Enyedy IJ, Li P, Hong VS, McKenzie A, Biamonte MA.
J Med Chem (2012) 55 : 7786 -7795
PubMed 22938030 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.21 7.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1230584 1 7.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1230584 Ki = 61.0 nM 7.21