Assay Detail
Binding
CHEMBL2212645
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Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
EC144 is a potent inhibitor of the heat shock protein 90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.60 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.15 |
| CHEMBL2205799 | — | — | 1 | 8.05 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.92 |
| CHEMBL1230584 | — | — | 1 | 7.85 |
| CHEMBL2205798 | — | — | 1 | 7.82 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 7.72 |
| CHEMBL2205245 | — | — | 1 | 7.58 |
| CHEMBL2205800 | — | — | 1 | 7.50 |
| CHEMBL467399 | BIIB021 | 2.0 | 1 | 7.42 |
| CHEMBL2205243 | — | — | 1 | 7.01 |
| CHEMBL2205244 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2205799 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1230584 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2205798 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL560895 | SNX-2112 | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2205245 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2205800 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL467399 | BIIB021 | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2205243 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL2205244 | — | EC50 | = | 250.0 | nM | 6.60 |