Assay Detail
Binding
CHEMBL2212667
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Modulation of gamma secretase in CHO-2B7 cells assessed as reduction in amyloid beta 38 level after 5 hrs by MSD ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO-2B7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a natural product-based class of γ-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.61 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206994 | — | — | 1 | 6.80 |
| CHEMBL2207044 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206994 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2207044 | — | IC50 | = | 380.0 | nM | 6.42 |