Assay Detail
Binding
CHEMBL2212808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior to substrate addition measured after 10 to 30 mins by enzyme immunoassay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azabenzthiazole inhibitors of leukotriene A₄ hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207747 | — | — | 1 | 9.52 |
| CHEMBL2207751 | — | — | 1 | 9.00 |
| CHEMBL2207749 | — | — | 1 | 8.52 |
| CHEMBL2207730 | — | — | 1 | 8.52 |
| CHEMBL2207742 | — | — | 1 | 8.52 |
| CHEMBL2207741 | — | — | 1 | 8.40 |
| CHEMBL2207750 | — | — | 1 | 8.30 |
| CHEMBL2207752 | — | — | 1 | 8.22 |
| CHEMBL2207738 | — | — | 1 | 8.22 |
| CHEMBL2207745 | — | — | 1 | 8.22 |
| CHEMBL2207748 | — | — | 1 | 8.22 |
| CHEMBL2207739 | — | — | 1 | 8.15 |
| CHEMBL2207740 | — | — | 1 | 8.15 |
| CHEMBL2207736 | — | — | 1 | 8.10 |
| CHEMBL2207743 | — | — | 1 | 7.96 |
| CHEMBL2207744 | — | — | 1 | 7.85 |
| CHEMBL2207746 | — | — | 1 | 7.85 |
| CHEMBL2207737 | — | — | 1 | 7.80 |
| CHEMBL2207735 | — | — | 1 | 7.54 |
| CHEMBL2207733 | — | — | 1 | 7.48 |
| CHEMBL2207734 | — | — | 1 | 7.40 |
| CHEMBL2207731 | — | — | 1 | 6.21 |
| CHEMBL2207729 | — | — | 1 | 6.13 |
| CHEMBL2207732 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207747 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2207751 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2207749 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2207730 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2207742 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2207741 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2207750 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2207752 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2207738 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2207745 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2207748 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2207739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2207740 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2207736 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2207743 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2207744 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2207746 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2207737 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2207735 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2207733 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2207734 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2207731 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL2207729 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL2207732 | — | IC50 | = | 1800.0 | nM | 5.75 |