Assay Detail
Binding
CHEMBL2212819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.01 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203332 | — | — | 1 | 8.85 |
| CHEMBL2207756 | — | — | 1 | 8.29 |
| CHEMBL2181036 | — | — | 1 | 6.61 |
| CHEMBL207649 | — | — | 1 | 5.79 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 5.49 |
| CHEMBL2069534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203332 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL2207756 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL2181036 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL207649 | — | IC50 | = | 1635.0 | nM | 5.79 |
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | IC50 | = | 3255.0 | nM | 5.49 |
| CHEMBL2069534 | — | IC50 | > | 10000.0 | nM | - |