Assay Detail
Binding
CHEMBL2212889
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Inhibition of DGAT in rat liver microsomes
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL6129) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.93 | 5.51 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473967 | — | — | 1 | 5.51 |
| CHEMBL2207805 | — | — | 1 | 5.36 |
| CHEMBL2207808 | — | — | 1 | 5.06 |
| CHEMBL2207794 | — | — | 1 | 5.05 |
| CHEMBL2207809 | — | — | 1 | 5.02 |
| CHEMBL243796 | KURARINONE | — | 1 | 4.96 |
| CHEMBL2207799 | — | — | 1 | 4.95 |
| CHEMBL2207807 | — | — | 1 | 4.94 |
| CHEMBL2207804 | — | — | 1 | 4.70 |
| CHEMBL2207798 | — | — | 1 | 4.70 |
| CHEMBL2205735 | — | — | 1 | 4.64 |
| CHEMBL2207806 | — | — | 1 | 4.59 |
| CHEMBL2207800 | — | — | 1 | 4.56 |
| CHEMBL253896 | XANTHOHUMOL | 2.0 | 1 | - |
| CHEMBL2207810 | — | — | 1 | - |
| CHEMBL2207803 | — | — | 1 | - |
| CHEMBL2207802 | — | — | 1 | - |
| CHEMBL2207801 | — | — | 1 | - |
| CHEMBL2207811 | — | — | 1 | - |
| CHEMBL2207812 | — | — | 1 | - |
| CHEMBL2207797 | — | — | 1 | - |
| CHEMBL2207796 | — | — | 1 | - |
| CHEMBL2207795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473967 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2207805 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2207808 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL2207794 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2207809 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL243796 | KURARINONE | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL2207799 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL2207807 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL2207804 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2207798 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2205735 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2207806 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL2207800 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL253896 | XANTHOHUMOL | Inhibition | - | % | - | |
| CHEMBL2207810 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207803 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207802 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207801 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207811 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207812 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207797 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207796 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2207795 | — | IC50 | > | 50000.0 | nM | - |