Assay Detail
Functional
CHEMBL2212937
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Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.94 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206264 | — | — | 1 | 9.28 |
| CHEMBL269004 | — | — | 1 | 9.20 |
| CHEMBL2206265 | — | — | 1 | 9.03 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206264 | — | EC50 | = | 0.53 | nM | 9.28 |
| CHEMBL269004 | — | EC50 | = | 0.63 | nM | 9.20 |
| CHEMBL2206265 | — | EC50 | = | 0.94 | nM | 9.03 |
| CHEMBL59 | DOPAMINE | EC50 | = | 5.8 | nM | 8.24 |