Assay Detail
Binding
CHEMBL2213149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of gamma secretase in CHO-2B7 cells assessed as reduction in amyloid beta 40 level after 5 hrs by MSD ELISA
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO-2B7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a natural product-based class of γ-secretase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 5.26 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207031 | — | — | 1 | 6.32 |
| CHEMBL2207000 | — | — | 1 | 6.01 |
| CHEMBL2207038 | — | — | 1 | 6.00 |
| CHEMBL2207449 | — | — | 1 | 5.92 |
| CHEMBL2207051 | — | — | 1 | 5.89 |
| CHEMBL2207025 | — | — | 1 | 5.85 |
| CHEMBL2207069 | — | — | 1 | 5.85 |
| CHEMBL2207443 | — | — | 1 | 5.77 |
| CHEMBL2206988 | — | — | 1 | 5.72 |
| CHEMBL2207458 | — | — | 1 | 5.72 |
| CHEMBL2207454 | — | — | 1 | 5.70 |
| CHEMBL2206994 | — | — | 1 | 5.68 |
| CHEMBL2152870 | — | — | 1 | 5.66 |
| CHEMBL2206993 | — | — | 1 | 5.62 |
| CHEMBL2206996 | — | — | 1 | 5.60 |
| CHEMBL2207009 | — | — | 1 | 5.60 |
| CHEMBL2207462 | — | — | 1 | 5.58 |
| CHEMBL2207043 | — | — | 1 | 5.57 |
| CHEMBL2207066 | — | — | 1 | 5.55 |
| CHEMBL2207008 | — | — | 1 | 5.54 |
| CHEMBL2207050 | — | — | 1 | 5.54 |
| CHEMBL2206989 | — | — | 1 | 5.52 |
| CHEMBL2206997 | — | — | 1 | 5.51 |
| CHEMBL2207049 | — | — | 1 | 5.50 |
| CHEMBL2206995 | — | — | 1 | 5.46 |
| CHEMBL2207045 | — | — | 1 | 5.43 |
| CHEMBL2207448 | — | — | 1 | 5.41 |
| CHEMBL2207459 | — | — | 1 | 5.40 |
| CHEMBL2207001 | — | — | 1 | 5.37 |
| CHEMBL2207444 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207031 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2207000 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2207038 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2207449 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2207051 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2207025 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2207069 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2207443 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2206988 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2207458 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2207454 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2206994 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2152870 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2206993 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2207009 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2206996 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2207462 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2207043 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2207066 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2207008 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2207050 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2206989 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2206997 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2207049 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2206995 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL2207045 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2207448 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2207459 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2207001 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2207444 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2207042 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2207065 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2207046 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2206991 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2207005 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2206999 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2207464 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2207460 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2207037 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2207014 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2207034 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2207062 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2206992 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2207445 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2207039 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2207068 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2206990 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL2206985 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2207053 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2207040 | — | IC50 | = | 6400.0 | nM | 5.19 |