Assay Detail
Binding
CHEMBL2213352
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Inhibition of TNFalpha-induced NF-kappaB activity expressed in HEK293 cells by luciferase reporter gene assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.06 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 6.01 |
| CHEMBL2208131 | — | — | 1 | 5.57 |
| CHEMBL60718 | TPCK | — | 1 | 5.29 |
| CHEMBL2208141 | — | — | 1 | 4.69 |
| CHEMBL2208140 | — | — | 1 | 4.50 |
| CHEMBL264401 | — | — | 1 | 4.32 |
| CHEMBL1939530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL165 | RESVERATROL | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2208131 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL60718 | TPCK | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL2208141 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL2208140 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL264401 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL1939530 | — | IC50 | > | 50000.0 | nM | - |