Assay Detail
Binding
CHEMBL2213420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 mins
3
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Microtubule-associated protein tau (CHEMBL1293224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Bmax | 1 | - | - |
| Kd | 1 | 9.15 | 9.15 |
| Ki | 1 | 8.60 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203439 | — | — | 2 | 9.15 |
| CHEMBL480 | LANSOPRAZOLE | 4.0 | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203439 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL480 | LANSOPRAZOLE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2203439 | — | Bmax | = | 0.214 | fmol/ug | - |