Assay Detail
Functional
CHEMBL2213508
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Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.58 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2206890 | — | — | 1 | 8.34 |
| CHEMBL2206404 | — | — | 1 | 8.17 |
| CHEMBL2206375 | — | — | 1 | 7.64 |
| CHEMBL2206381 | — | — | 1 | 7.43 |
| CHEMBL2206388 | — | — | 1 | 7.40 |
| CHEMBL2206371 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2206890 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL2206404 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL2206375 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2206381 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL2206388 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2206371 | — | EC50 | = | 320.0 | nM | 6.50 |