Assay Detail
Binding
CHEMBL2213652
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Negative allosteric modulation of mGlu2 by cell-based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.53 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1629855 | — | — | 1 | 6.53 |
| CHEMBL2204446 | — | — | 1 | - |
| CHEMBL2204445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1629855 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL2204446 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2204445 | — | IC50 | > | 10000.0 | nM | - |