Assay Detail
Functional
CHEMBL2213716
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Antiviral activity against HCV genotype 1b Con1 infected in human Huh7 cells assessed as inhibition of viral replication in presence of 10% FBS by HCV bicistronic replicon assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.58 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203882 | — | — | 1 | 8.64 |
| CHEMBL2203892 | — | — | 1 | 8.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203882 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2203892 | — | IC50 | = | 3.1 | nM | 8.51 |