Assay Detail
Functional
CHEMBL2213722
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Antiviral activity against HCV genotype 1b Con1 infected in human Huh7 cells assessed as inhibition of viral replication in presence of 50% NHS by HCV bicistronic replicon assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.62 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203293 | — | — | 1 | 8.30 |
| CHEMBL2203887 | — | — | 1 | 8.05 |
| CHEMBL2203882 | — | — | 1 | 7.96 |
| CHEMBL2203881 | — | — | 1 | 7.80 |
| CHEMBL2203874 | — | — | 1 | 7.77 |
| CHEMBL2203890 | — | — | 1 | 7.75 |
| CHEMBL2203879 | — | — | 1 | 7.75 |
| CHEMBL2203886 | — | — | 1 | 7.64 |
| CHEMBL2203878 | — | — | 1 | 7.62 |
| CHEMBL2203883 | — | — | 1 | 7.60 |
| CHEMBL2203876 | — | — | 1 | 7.60 |
| CHEMBL2203885 | — | — | 1 | 7.54 |
| CHEMBL2203893 | — | — | 1 | 7.51 |
| CHEMBL2203892 | — | — | 1 | 7.50 |
| CHEMBL2203888 | — | — | 1 | 7.50 |
| CHEMBL2203877 | — | — | 1 | 7.42 |
| CHEMBL2203884 | — | — | 1 | 7.37 |
| CHEMBL2203875 | — | — | 1 | 7.26 |
| CHEMBL2203891 | — | — | 1 | 7.24 |
| CHEMBL2203889 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203293 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2203887 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2203882 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2203881 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2203874 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2203890 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2203879 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2203886 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2203878 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2203883 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2203876 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2203885 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL2203893 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2203892 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2203888 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2203877 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2203884 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2203875 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2203891 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2203889 | — | IC50 | = | 64.0 | nM | 7.19 |