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Assay Detail

CHEMBL2213724

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV genotype 1b BK NS3/4A protease expressed in Escherichia coli incubated for 30 mins by time-resolved fluorescence assay
ChEMBL ↗
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus (isolate BK)
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Rudd MT, McIntyre CJ, Romano JJ, Butcher JW, Holloway MK, Bush K, Nguyen KT, Gilbert KF, Lyle TA, Liverton NJ, Wan BL, Summa V, Harper S, Rowley M, Vacca JP, Carroll SS, Burlein C, DiMuzio JM, Gates A, Graham DJ, Huang Q, Ludmerer SW, McClain S, McHale C, Stahlhut M, Fandozzi C, Taylor A, Trainor N, Olsen DB, McCauley JA.
Bioorg Med Chem Lett (2012) 22 : 7207 -7213
PubMed 23084906 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 10.80 10.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2203882 — — 1 10.80
CHEMBL2203873 — — 1 10.80
CHEMBL2203892 — — 1 10.80
CHEMBL2203875 — — 1 -
CHEMBL2203876 — — 1 -
CHEMBL2203877 — — 1 -
CHEMBL2203878 — — 1 -
CHEMBL2203879 — — 1 -
CHEMBL2203880 — — 1 -
CHEMBL2203881 — — 1 -
CHEMBL2203883 — — 1 -
CHEMBL2203884 — — 1 -
CHEMBL2203885 — — 1 -
CHEMBL2203887 — — 1 -
CHEMBL2203888 — — 1 -
CHEMBL2203889 — — 1 -
CHEMBL2203890 — — 1 -
CHEMBL2203891 — — 1 -
CHEMBL2203293 — — 1 -
CHEMBL2203893 — — 1 -
CHEMBL2203894 — — 1 -
CHEMBL2203895 — — 1 -
CHEMBL2203874 — — 1 -
CHEMBL2203886 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2203882 — Ki = 0.016 nM 10.80
CHEMBL2203873 — Ki = 0.016 nM 10.80
CHEMBL2203892 — Ki = 0.016 nM 10.80
CHEMBL2203875 — Ki < 0.05 nM -
CHEMBL2203876 — Ki < 0.05 nM -
CHEMBL2203877 — Ki < 0.05 nM -
CHEMBL2203878 — Ki < 0.05 nM -
CHEMBL2203879 — Ki < 0.05 nM -
CHEMBL2203880 — Ki < 0.05 nM -
CHEMBL2203881 — Ki < 0.05 nM -
CHEMBL2203883 — Ki < 0.05 nM -
CHEMBL2203884 — Ki < 0.05 nM -
CHEMBL2203885 — Ki < 0.05 nM -
CHEMBL2203887 — Ki < 0.05 nM -
CHEMBL2203888 — Ki < 0.05 nM -
CHEMBL2203889 — Ki < 0.05 nM -
CHEMBL2203890 — Ki < 0.05 nM -
CHEMBL2203891 — Ki < 0.05 nM -
CHEMBL2203293 — Ki < 0.05 nM -
CHEMBL2203893 — Ki < 0.05 nM -
CHEMBL2203894 — Ki < 0.05 nM -
CHEMBL2203895 — Ki < 0.05 nM -
CHEMBL2203874 — Ki < 0.05 nM -
CHEMBL2203886 — Ki < 0.05 nM -