Assay Detail
Functional
CHEMBL2214126
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Antiproliferative activity at human A549 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.34 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203738 | — | — | 1 | 9.00 |
| CHEMBL2203739 | — | — | 1 | 8.40 |
| CHEMBL2203744 | — | — | 1 | 8.40 |
| CHEMBL2203740 | — | — | 1 | 8.00 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.70 |
| CHEMBL385064 | — | — | 1 | 7.70 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.10 |
| CHEMBL390195 | — | — | 1 | 5.66 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203738 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2203739 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2203744 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2203740 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL385064 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL390195 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 7500.0 | nM | 5.12 |