Assay Detail
Functional
CHEMBL2214131
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Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.56 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2203740 | — | — | 1 | 8.40 |
| CHEMBL385064 | — | — | 1 | 8.40 |
| CHEMBL2203741 | — | — | 1 | 8.30 |
| CHEMBL2203745 | — | — | 1 | 8.22 |
| CHEMBL2203742 | — | — | 1 | 8.22 |
| CHEMBL2203743 | — | — | 1 | 8.00 |
| CHEMBL2203746 | — | — | 1 | 7.96 |
| CHEMBL442071 | — | — | 1 | 7.92 |
| CHEMBL2203744 | — | — | 1 | 7.89 |
| CHEMBL231621 | — | — | 1 | 7.75 |
| CHEMBL275925 | — | — | 1 | 7.70 |
| CHEMBL413443 | — | — | 1 | 7.22 |
| CHEMBL438288 | — | — | 1 | 6.52 |
| CHEMBL390195 | — | — | 1 | 5.96 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2203740 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL385064 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2203741 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2203745 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2203742 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2203743 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2203746 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL442071 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2203744 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL231621 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL275925 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL413443 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL438288 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL390195 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 10000.0 | nM | 5.00 |