Assay Detail
Binding
CHEMBL2214225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 capsid protein assembly using 5'-fluorescein-labeled (TG)25 oligonucleotide after 2 hrs by fluorometry-based capsid disassembly assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.62 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204005 | — | — | 1 | 7.39 |
| CHEMBL2204007 | — | — | 1 | 7.31 |
| CHEMBL2204004 | — | — | 1 | 7.26 |
| CHEMBL2204006 | — | — | 1 | 7.25 |
| CHEMBL2204002 | — | — | 1 | 7.06 |
| CHEMBL2204003 | — | — | 1 | 6.92 |
| CHEMBL2204016 | — | — | 1 | 6.77 |
| CHEMBL2204001 | — | — | 1 | 6.55 |
| CHEMBL2204013 | — | — | 1 | 6.44 |
| CHEMBL2204000 | — | — | 1 | 6.39 |
| CHEMBL2204014 | — | — | 1 | 6.10 |
| CHEMBL2204015 | — | — | 1 | 6.08 |
| CHEMBL2204012 | — | — | 1 | 6.00 |
| CHEMBL2204011 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204005 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2204007 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2204004 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2204006 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL2204002 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL2204003 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2204016 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2204001 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2204013 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2204000 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2204014 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2204015 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2204012 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2204011 | — | IC50 | = | 6000.0 | nM | 5.22 |