Assay Detail
Functional
CHEMBL2214272
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Partial agonist activity at human dopamine D4.2 receptor expressed in CHO10001 cells assessed as stimulation of mitogenesis measuring [3H]thymidine incorporation after 20 hrs by scintillation counting analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO10001 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel azulene derivatives for the treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 9.04 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2207637 | — | — | 1 | 9.39 |
| CHEMBL2207635 | — | — | 1 | 9.03 |
| CHEMBL2207641 | — | — | 1 | 9.01 |
| CHEMBL2207643 | — | — | 1 | 8.92 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2207637 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL2207635 | — | EC50 | = | 0.94 | nM | 9.03 |
| CHEMBL2207641 | — | EC50 | = | 0.98 | nM | 9.01 |
| CHEMBL2207643 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 1.4 | nM | 8.85 |