Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2214283

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells after 60 mins by scintillation counting analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel azulene derivatives for the treatment of erectile dysfunction.
Löber S, Hübner H, Buschauer A, Sanna F, Argiolas A, Melis MR, Gmeiner P.
Bioorg Med Chem Lett (2012) 22 : 7151 -7154
PubMed 23099096 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.22 8.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2207636 1 8.08
CHEMBL2207641 1 7.77
CHEMBL2207643 1 7.48
CHEMBL2207638 1 7.29
CHEMBL2207640 1 7.22
CHEMBL2207633 1 7.19
CHEMBL2207634 1 7.12
CHEMBL2207642 1 7.02
CHEMBL2207632 1 7.02
CHEMBL2207639 1 6.89
CHEMBL2207635 1 6.82
CHEMBL2207637 1 6.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2207636 Ki = 8.3 nM 8.08
CHEMBL2207641 Ki = 17.0 nM 7.77
CHEMBL2207643 Ki = 33.0 nM 7.48
CHEMBL2207638 Ki = 51.0 nM 7.29
CHEMBL2207640 Ki = 60.0 nM 7.22
CHEMBL2207633 Ki = 65.0 nM 7.19
CHEMBL2207634 Ki = 76.0 nM 7.12
CHEMBL2207642 Ki = 95.0 nM 7.02
CHEMBL2207632 Ki = 95.0 nM 7.02
CHEMBL2207639 Ki = 130.0 nM 6.89
CHEMBL2207635 Ki = 150.0 nM 6.82
CHEMBL2207637 Ki = 210.0 nM 6.68