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Assay Detail

CHEMBL2215085

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Physicochemical
Binding affinity to Zn(II) after 2 hrs using FluoZin-3 by fuorescence assay
ChEMBL ↗
44
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Physicochemical
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

No relevant target (CHEMBL2362975) ↗
Type NO TARGET

Publication

Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors.
Thiele S, Malmgaard-Clausen M, Engel-Andreasen J, Steen A, Rummel PC, Nielsen MC, Gloriam DE, Frimurer TM, Ulven T, Rosenkilde MM.
J Med Chem (2012) 55 : 8164 -8177
PubMed 22957890 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.83 7.10
pIC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2205804 — — 2 7.10
CHEMBL89445 TERPYRIDINE — 2 6.82
CHEMBL99384 — — 2 6.80
CHEMBL98682 — — 2 6.70
CHEMBL316589 — — 2 6.60
CHEMBL593442 — — 2 6.51
CHEMBL1976682 — — 2 6.50
CHEMBL2205810 — — 2 6.40
CHEMBL2205805 — — 2 6.23
CHEMBL2205809 — — 2 6.10
CHEMBL317115 — — 2 6.00
CHEMBL415879 PHENANTHROLINE — 2 5.96
CHEMBL2205808 — — 2 5.70
CHEMBL101165 — — 2 5.54
CHEMBL2205807 ABAMETAPIR 4.0 2 5.35
CHEMBL1623498 — — 2 5.23
CHEMBL375781 NEOCUPROINE — 2 5.10
CHEMBL2205802 — — 2 4.60
CHEMBL39879 DIPYRIDYL — 2 4.30
CHEMBL2205803 — — 2 4.20
CHEMBL2205806 — — 2 4.00
CHEMBL2205801 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2205804 — IC50 = 80.0 nM 7.10
CHEMBL2205804 — IC50 = 79.43 nM 7.10
CHEMBL89445 TERPYRIDINE IC50 = 150.0 nM 6.82
CHEMBL89445 TERPYRIDINE IC50 = 158.49 nM 6.80
CHEMBL99384 — IC50 = 160.0 nM 6.80
CHEMBL99384 — IC50 = 158.49 nM 6.80
CHEMBL98682 — IC50 = 199.53 nM 6.70
CHEMBL98682 — IC50 = 210.0 nM 6.68
CHEMBL316589 — IC50 = 251.19 nM 6.60
CHEMBL316589 — IC50 = 270.0 nM 6.57
CHEMBL593442 — IC50 = 310.0 nM 6.51
CHEMBL593442 — IC50 = 316.23 nM 6.50
CHEMBL1976682 — IC50 = 316.23 nM 6.50
CHEMBL1976682 — IC50 = 330.0 nM 6.48
CHEMBL2205810 — IC50 = 398.11 nM 6.40
CHEMBL2205810 — IC50 = 430.0 nM 6.37
CHEMBL2205805 — IC50 = 590.0 nM 6.23
CHEMBL2205805 — IC50 = 630.96 nM 6.20
CHEMBL2205809 — IC50 = 794.33 nM 6.10
CHEMBL2205809 — IC50 = 870.0 nM 6.06
CHEMBL317115 — IC50 = 1000.0 nM 6.00
CHEMBL317115 — IC50 = 1000.0 nM 6.00
CHEMBL415879 PHENANTHROLINE IC50 = 1100.0 nM 5.96
CHEMBL415879 PHENANTHROLINE IC50 = 1258.93 nM 5.90
CHEMBL2205808 — IC50 = 1995.26 nM 5.70
CHEMBL2205808 — IC50 = 2000.0 nM 5.70
CHEMBL101165 — IC50 = 2900.0 nM 5.54
CHEMBL101165 — IC50 = 3162.28 nM 5.50
CHEMBL2205807 ABAMETAPIR IC50 = 4500.0 nM 5.35
CHEMBL2205807 ABAMETAPIR IC50 = 5011.87 nM 5.30
CHEMBL1623498 — IC50 = 5900.0 nM 5.23
CHEMBL1623498 — IC50 = 6309.57 nM 5.20
CHEMBL375781 NEOCUPROINE IC50 = 7943.28 nM 5.10
CHEMBL375781 NEOCUPROINE IC50 = 8400.0 nM 5.08
CHEMBL2205802 — IC50 = 25118.86 nM 4.60
CHEMBL2205802 — IC50 = 25000.0 nM 4.60
CHEMBL39879 DIPYRIDYL IC50 = 50118.72 nM 4.30
CHEMBL39879 DIPYRIDYL IC50 = 54000.0 nM 4.27
CHEMBL2205803 — IC50 = 63095.73 nM 4.20
CHEMBL2205803 — IC50 = 64000.0 nM 4.19
CHEMBL2205806 — IC50 = 100000.0 nM 4.00
CHEMBL2205801 — IC50 - — -
CHEMBL2205801 — pIC50 - — -
CHEMBL2205806 — IC50 = 110000.0 nM -