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Assay Detail

CHEMBL2215248

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide FF receptor 2 (CHEMBL5952)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.
Gealageas R, Schneider S, Humbert JP, Bertin I, Schmitt M, Laboureyras E, Dugave C, Mollereau C, Simonnet G, Bourguignon JJ, Simonin F, Bihel F.
Bioorg Med Chem Lett (2012) 22 : 7471 -7474
PubMed 23131340 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 6.84 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2208319 1 8.40
CHEMBL2208338 1 8.40
CHEMBL2208322 1 8.05
CHEMBL2208340 1 7.66
CHEMBL1672380 1 7.37
CHEMBL2208312 1 7.33
CHEMBL2208339 1 7.04
CHEMBL2208325 1 7.03
CHEMBL2208303 1 6.93
CHEMBL2208296 1 6.87
CHEMBL2208294 1 6.85
CHEMBL2208305 1 6.85
CHEMBL2208320 1 6.81
CHEMBL2208334 1 6.69
CHEMBL2208307 1 6.68
CHEMBL2208299 1 6.64
CHEMBL2208326 1 6.38
CHEMBL2208306 1 6.37
CHEMBL2208316 1 6.37
CHEMBL2208337 1 6.23
CHEMBL2208323 1 6.17
CHEMBL2208304 1 5.79
CHEMBL2204019 1 5.70
CHEMBL2208317 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2208319 Ki = 4.0 nM 8.40
CHEMBL2208338 Ki = 4.0 nM 8.40
CHEMBL2208322 Ki = 9.0 nM 8.05
CHEMBL2208340 Ki = 22.0 nM 7.66
CHEMBL1672380 Ki = 43.0 nM 7.37
CHEMBL2208312 Ki = 47.0 nM 7.33
CHEMBL2208339 Ki = 92.0 nM 7.04
CHEMBL2208325 Ki = 94.0 nM 7.03
CHEMBL2208303 Ki = 117.0 nM 6.93
CHEMBL2208296 Ki = 136.0 nM 6.87
CHEMBL2208294 Ki = 141.0 nM 6.85
CHEMBL2208305 Ki = 142.0 nM 6.85
CHEMBL2208320 Ki = 155.0 nM 6.81
CHEMBL2208334 Ki = 206.0 nM 6.69
CHEMBL2208307 Ki = 208.0 nM 6.68
CHEMBL2208299 Ki = 227.0 nM 6.64
CHEMBL2208326 Ki = 417.0 nM 6.38
CHEMBL2208306 Ki = 424.0 nM 6.37
CHEMBL2208316 Ki = 425.0 nM 6.37
CHEMBL2208337 Ki = 590.0 nM 6.23
CHEMBL2208323 Ki = 672.0 nM 6.17
CHEMBL2208304 Ki = 1620.0 nM 5.79
CHEMBL2204019 Ki = 2015.0 nM 5.70
CHEMBL2208317 Ki = 3196.0 nM 5.50