Assay Detail
Functional
CHEMBL2215318
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Antiviral activity against HCV subtype 1b expressing NS3/4A D168V mutant protease infected in ET cells after 72 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | ET |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.57 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 7.58 |
| CHEMBL2208397 | — | — | 1 | 7.57 |
| CHEMBL2208398 | — | — | 1 | 7.29 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 6.85 |
| CHEMBL2208373 | — | — | 1 | 6.82 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.68 |
| CHEMBL2208365 | — | — | 1 | 6.63 |
| CHEMBL2208400 | — | — | 1 | 6.58 |
| CHEMBL2208364 | — | — | 1 | 6.08 |
| CHEMBL2208396 | — | — | 1 | 5.78 |
| CHEMBL2208366 | — | — | 1 | 5.52 |
| CHEMBL2208367 | — | — | 1 | 5.40 |
| CHEMBL2208374 | — | — | 1 | - |
| CHEMBL2208399 | — | — | 1 | - |
| CHEMBL2208368 | — | — | 1 | - |
| CHEMBL2208369 | — | — | 1 | - |
| CHEMBL2208370 | — | — | 1 | - |
| CHEMBL2208371 | — | — | 1 | - |
| CHEMBL2208372 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258734 | DANOPREVIR | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL2208397 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2208398 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL501849 | SIMEPREVIR | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2208373 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL2208365 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL2208400 | — | EC50 | = | 263.0 | nM | 6.58 |
| CHEMBL2208364 | — | EC50 | = | 832.0 | nM | 6.08 |
| CHEMBL2208396 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL2208366 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL2208367 | — | EC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL2208374 | — | EC50 | - | — | - | |
| CHEMBL2208399 | — | EC50 | - | — | - | |
| CHEMBL2208368 | — | EC50 | - | — | - | |
| CHEMBL2208369 | — | EC50 | - | — | - | |
| CHEMBL2208370 | — | EC50 | - | — | - | |
| CHEMBL2208371 | — | EC50 | - | — | - | |
| CHEMBL2208372 | — | EC50 | - | — | - |