Assay Detail
Functional
CHEMBL2215324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV subtype 1b infected in human hepatoma cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 9.01 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208400 | — | — | 1 | 10.00 |
| CHEMBL2208397 | — | — | 1 | 9.70 |
| CHEMBL2208398 | — | — | 1 | 9.70 |
| CHEMBL2208399 | — | — | 1 | 9.70 |
| CHEMBL2208365 | — | — | 1 | 9.52 |
| CHEMBL2208374 | — | — | 1 | 9.40 |
| CHEMBL2208373 | — | — | 1 | 9.40 |
| CHEMBL2208372 | — | — | 1 | 9.40 |
| CHEMBL2208371 | — | — | 1 | 9.30 |
| CHEMBL2208368 | — | — | 1 | 9.22 |
| CHEMBL2208370 | — | — | 1 | 9.15 |
| CHEMBL2208364 | — | — | 1 | 9.15 |
| CHEMBL2208396 | — | — | 1 | 9.00 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 9.00 |
| CHEMBL2208369 | — | — | 1 | 8.92 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.82 |
| CHEMBL2208366 | — | — | 1 | 7.85 |
| CHEMBL2208367 | — | — | 1 | 7.62 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208400 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2208397 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2208398 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2208399 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL2208365 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2208374 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2208373 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2208372 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL2208371 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2208368 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2208370 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2208364 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2208396 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL501849 | SIMEPREVIR | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2208369 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL258734 | DANOPREVIR | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2208366 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2208367 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 372.0 | nM | 6.43 |