Assay Detail
Binding
CHEMBL2215732
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Inhibition of GSK3beta by kinase-glo assay method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.69 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284861 | — | — | 1 | 5.85 |
| CHEMBL2207940 | — | — | 1 | 4.60 |
| CHEMBL2207939 | — | — | 1 | 4.57 |
| CHEMBL2207946 | — | — | 1 | 4.32 |
| CHEMBL2207938 | — | — | 1 | 4.11 |
| CHEMBL2207947 | — | — | 1 | - |
| CHEMBL1492321 | — | — | 1 | - |
| CHEMBL2207945 | — | — | 1 | - |
| CHEMBL2207944 | — | — | 1 | - |
| CHEMBL2207943 | — | — | 1 | - |
| CHEMBL2207942 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284861 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2207940 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2207939 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL2207946 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL2207938 | — | IC50 | = | 77200.0 | nM | 4.11 |
| CHEMBL2207947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1492321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2207945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2207944 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2207943 | — | IC50 | = | 480000.0 | nM | - |
| CHEMBL2207942 | — | IC50 | = | 830000.0 | nM | - |