Assay Detail
Binding
CHEMBL2215774
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Inhibition of HCV subtype 1a NS3/4A protease (Ac-DE-Dap(QXL520)-EE-Abu-psi-[COO]-ASC(5-FAMsp)-NH2 as substrate by FRET analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.55 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2208397 | — | — | 1 | 9.30 |
| CHEMBL2208398 | — | — | 1 | 9.22 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 9.15 |
| CHEMBL2208368 | — | — | 1 | 9.10 |
| CHEMBL2208373 | — | — | 1 | 9.00 |
| CHEMBL2208369 | — | — | 1 | 9.00 |
| CHEMBL2208396 | — | — | 1 | 8.89 |
| CHEMBL2208372 | — | — | 1 | 8.89 |
| CHEMBL2208399 | — | — | 1 | 8.80 |
| CHEMBL2208400 | — | — | 1 | 8.70 |
| CHEMBL2208364 | — | — | 1 | 8.60 |
| CHEMBL2208366 | — | — | 1 | 8.60 |
| CHEMBL2208370 | — | — | 1 | 8.40 |
| CHEMBL2208365 | — | — | 1 | 8.40 |
| CHEMBL2208374 | — | — | 1 | 8.20 |
| CHEMBL2208371 | — | — | 1 | 8.20 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 8.00 |
| CHEMBL2208367 | — | — | 1 | 7.70 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2208397 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2208398 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL258734 | DANOPREVIR | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL2208368 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL2208373 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2208369 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2208396 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2208372 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2208399 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2208400 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2208364 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2208366 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2208370 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2208365 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2208374 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL2208371 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL501849 | SIMEPREVIR | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2208367 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL231813 | TELAPREVIR | IC50 | = | 500.0 | nM | 6.30 |