Assay Detail
Binding
CHEMBL2215836
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Inhibition of NET-mediated [3H]NE in rat synaptosomes by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.68 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204357 | — | — | 1 | 7.05 |
| CHEMBL2204359 | — | — | 1 | 6.92 |
| CHEMBL2204356 | — | — | 1 | 6.92 |
| CHEMBL2204360 | — | — | 1 | 6.85 |
| CHEMBL2205043 | — | — | 1 | 6.80 |
| CHEMBL2204363 | — | — | 1 | 6.47 |
| CHEMBL2205045 | — | — | 1 | 6.34 |
| CHEMBL2205054 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204357 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2204359 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2204356 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2204360 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2205043 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2204363 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2205045 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2205054 | — | IC50 | = | 880.0 | nM | 6.06 |