Assay Detail
Binding
CHEMBL2215843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by filter binding assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.17 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 8.55 |
| CHEMBL2204363 | — | — | 1 | 8.14 |
| CHEMBL2204361 | — | — | 1 | 7.92 |
| CHEMBL2204362 | — | — | 1 | 7.77 |
| CHEMBL2204360 | — | — | 1 | 7.64 |
| CHEMBL2204359 | — | — | 1 | 7.58 |
| CHEMBL2205034 | — | — | 1 | 7.57 |
| CHEMBL2204357 | — | — | 1 | 7.54 |
| CHEMBL2205051 | — | — | 1 | 7.50 |
| CHEMBL2204358 | — | — | 1 | 7.50 |
| CHEMBL2205054 | — | — | 1 | 7.48 |
| CHEMBL2205042 | — | — | 1 | 7.44 |
| CHEMBL2205043 | — | — | 1 | 7.44 |
| CHEMBL2205031 | — | — | 1 | 7.35 |
| CHEMBL2205050 | — | — | 1 | 7.28 |
| CHEMBL2205044 | — | — | 1 | 7.28 |
| CHEMBL2205045 | — | — | 1 | 7.25 |
| CHEMBL2205048 | — | — | 1 | 7.21 |
| CHEMBL2205049 | — | — | 1 | 7.19 |
| CHEMBL2205041 | — | — | 1 | 7.19 |
| CHEMBL2204356 | — | — | 1 | 7.17 |
| CHEMBL2204355 | — | — | 1 | 7.10 |
| CHEMBL2205052 | — | — | 1 | 7.07 |
| CHEMBL2205053 | — | — | 1 | 6.96 |
| CHEMBL2205033 | — | — | 1 | 6.89 |
| CHEMBL2205046 | — | — | 1 | 6.85 |
| CHEMBL2204365 | — | — | 1 | 6.82 |
| CHEMBL2204364 | — | — | 1 | 6.80 |
| CHEMBL2205037 | — | — | 1 | 6.72 |
| CHEMBL2205040 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46 | ONDANSETRON | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL2204363 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL2204361 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2204362 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2204360 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2204359 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL2205034 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL2204357 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL2205051 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2204358 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2205054 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL2205042 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2205043 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2205031 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL2205044 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2205050 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL2205045 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL2205048 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2205041 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL2205049 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL2204356 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL2204355 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2205052 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL2205053 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2205033 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2205046 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2204365 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2204364 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2205037 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2205040 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2205035 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL2205036 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL2205039 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL2205047 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2205038 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL2205032 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL549 | CITALOPRAM | Ki | - | — | - | |
| CHEMBL49 | BUSPIRONE | Ki | > | 10000.0 | nM | - |