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Assay Detail

CHEMBL2216694

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of para-amino phenylmercuric acetate-activated MMP2 using Mca-P-L-G-L-Dap(Dnp)-A-R-NH2 as substrate after 1 hr by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of procollagen C-proteinase inhibitors.
Turtle E, Chow N, Yang C, Sosa S, Bauer U, Brenner M, Solow-Cordero D, Ho WB.
Bioorg Med Chem Lett (2012) 22 : 7397 -7401
PubMed 23134659 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 6.85 6.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL312218 1 6.85
CHEMBL2204087 1 -
CHEMBL2204807 1 -
CHEMBL2204802 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL312218 IC50 = 140.0 nM 6.85
CHEMBL2204087 IC50 > 25000.0 nM -
CHEMBL2204807 IC50 > 6000.0 nM -
CHEMBL2204802 IC50 > 25000.0 nM -